Lisa Julian

 Lisa Julian

Contact Information

600 S. Mathews Avenue
367B Noyes Lab, MC-712
Urbana, IL 61801
Lecturer
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Biography

Dr. Lisa Julian earned her Ph.D. in Organic Chemistry from the University of Michigan in 2005. Immediately following graduate school, she worked at Amgen as a Research Scientist in medicinal chemistry, but it wasn’t long before she realized that her true passion was in academia, teaching and working with students. After completion of her NIH postdoctoral fellowship at the University of Illinois, she continued her work in drug discovery research developing new “targeted” cancer therapies at the University of Colorado in Denver where she served as Assistant Professor of Chemistry from 2011-2015. 

Research Interests

  • She is a Visiting Lecturer in the Department for the 2018-2019 academic year teaching in the Organic Area.

Research Description

Lisa truly enjoys teaching and learning about “the molecules of life.” When she began to use her unique biomolecular training to understand human nutrition, she could see a clear connection between diet and disease. Her interests shifted from drug discovery and disease treatment to disease prevention and public health education. Specifically how the molecules in food (both natural and synthetic) are linked to cancer and other preventable chronic diseases in our society today.

She developed her concept the “Science of Food” into a full semester course for the University Honors and Leadership Program while she was at CU Denver in 2015 and taught Human Nutrition at Colorado Mountain College in Breckenridge from 2015-2018. She continues to educate the general public about diet and disease through her freelance writing and public cooking demonstrations in the community. 

PUBLISHED PATENT APPLICATIONS

“Cis-Morpholinone and Other Compounds as MDM2 Inhibitors for the Treatment of Cancer” Olson, S.; Medina, J.; Sun, D. Gonzalez Lopez De Turiso, F.; Fox, B.; Beck, H.; Yan, X.; Rew, Y.; DeGraffenreid, M.; Kayser, F.; Julian, L. PCT  Int. Appl. (2013) WO 61/766625.

“Preparation of tricyclic inhibitors of hydroxysteroid dehydrogenases” Powers, J. P.; Sun, D.; Yan, X.; Julian, L. D.; Gonzalez Lopez De Turiso, F. PCT Int. Appl. (2008) WO 08/156601.

“Benzamide derivatives useful in the treatment of hydroxysteroid dehydrogenase-mediated diseases and their preparation” Powers, J. P.; Degraffenreid, M.; Julian, L. D.; Kaizerman, J.; McMinn, D.; Rew, Y.; Sun, D.; Yan, X.; Wang, Z. PCT Int. Appl. (2007) WO 07/145835.

“Preparation of Benzamide Derivatives as Hydroxysteroid Dehydrogenase Modulators” Powers, J. P.; DeGraffenreid, M. R.; He, X.; Julian, L.; McMinn, D. L.; Sun, D.; Rew, Y.; Yan, X. PCT Int. Appl. (2006) WO 06/138508.

PRESENTATIONS

Mcnulty, O.; Moen, J.; Yan, C.; Julian, L. D. “Structure-Based Design and Synthesis of Mcl-1 Inhibitors for the Treatment of Multiple Myeloma” Regional Meeting of the American Chemical Society, Westminster, CO, October 17-20, 2012. 

Tyk, L.; Johnson-Sasso, C.; Julian, L.; Lin, H. “Structure-Based Design of Small Molecule Inhibitors of the Mcl-1 Protein” Regional Meeting of the American Chemical Society, Westminster, CO, October 17-20, 2012.

Julian, L. D.; Hartwig, J. F. “Intramolecular Hydroamination of Unbiased and Functionalized Primary Aminoalkenes Catalyzed by a Rhodium Aminophosphine Complex” Gordon Research Conference: Organometallic Chemistry, Newport RI, July 11-16th, 2010.

Julian, L. D.; Hartwig, J. F. “Rhodium-Catalyzed Hydroamination of Aminoalkenes: Scope and Mechanism.” 239th  National Meeting of the American Chemical Society, San Francisco, March 21-25, 2010.

Julian, L. D.; Hartwig, J. F. “Structure-Based Design of Rhodium Catalysts for Alkene Hydroamination.”  Gordon Research Conference: Organometallic Chemistry, Newport RI, July 12-17th, 2009.

Julian, L. D.; Bostick, T.; Caille, C.; Chan, H.; DeGraffenreid, M.; He, X.; Hungate, R.; Jaen, J.; Jiang, B.; Kaizerman, J.; Liu, J.; McMinn, D.; Powers, J. P.; Rew, Y.; Sudom, A.; Sun, D.; Tu, H.; Ursu, S.; Wang, Z.; Yan, X.; Ye, Q. “Discovery and Evaluation of Novel Benzamide Derivatives as Potent 11b-HSD1 Inhibitors for the Treatment of Type II Diabetes” 234th National Meeting of the American Chemical Society, Boston, August 19-23, 2007.

Julian, L. D.; Roush, W. R. “Studies Toward the Total Synthesis of the Tedanolides.” 229th  National Meeting of the American Chemical Society, San Diego, March 13-17, 2005.

 

Courses

  • Chemistry 532 Advanced Physical Organic Chemistry
  • Human Nutrition (HWE-100, Colorado Mountain College)
  • The Science of Food: Advanced Chemistry Elective (UCD)
  • The Science of Food: Understanding the Link between Diet, Culture and Disease (UCD)
  • Advanced Organic Synthesis (Graduate level course) (UCD)
  • Organic Chemistry I & II (UCD)

Selected Publications

Journal Articles

• Gonzalez-Lopez de Turiso, F, D. Sun, Y. Rew, M. D. Bartberger, H. Beck, J. Canon, A. Chen, D. Chow, T. L. Correll, X. Huang, L. D. Julian, F. Kayser, M. C. Lo, A. M. Long, D. McMinn, J. Oliner, T. Osgood, J. P. Powers, A. Y. Saiki, S. Schneider, P. Shaffer, S. H. Xioa, P. Yakowee, X. Yan, Q. Ye, D. Yu, X. Zhao, X. Zhou, J. C. Medina, and S. H. Olson Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors Journal of Medicinal Chemistry 56 10 2013, p. 4053-4070.
Sun, D, Z. Wang, S. Caille, M. DeGraffenreid, F. Gonzalez-Lopez de Turiso, R. Hungate, J. C. Jaen, B. Jiang, L. D. Julian, R. Kelly, D. L. McMinn, J. Kaizerman, Y. Rew, A. Sudom, H. Tu, S. Ursu, N. Walker, M. Willcockson, X. Yan, Q. Ye, and J. P. Powers Synthesis and Optimization of Novel 4,4-Disubstituted Cyclohexylbenzamide Derivatives as Potent 11ß-HSD1 Inhibitors Bioorganic and Medicinal Chemistry Letters 21 1 2011, p. 405-410.
Julian, L. D, and J. F. Hartwig Intramolecular Hydroamination of Unbiased and Functionalized Primary Aminoalkenes Catalyzed by a Rhodium Aminophosphine Complex Journal of the American Chemical Society 132 39 2010, p. 13813-13822.
McMinn, D, Y. Rew, A. Sudom, S. Caille, M. DeGraffenreid, X. He, R. W. Hungate, J. C. Jaen, B. Jiang, L. D. Julian, J. Kaizerman, P. Novak, D. Sun, H. Tu, S. Ursu, N. Walker, X. Yan, Q. Ye, Z. Wang, and J. P. Powers Optimization of Novel Di-substituted Cyclohexylbenzamide Derivatives as Potent 11ß-HSD1 Inhibitors Bioorganic and Medicinal Chemistry Letters 19 5 2009, p. 1446-1450.
Dunetz, J. R, L. D. Julian, J. S. Newcom, and W. R. Roush Total Syntheses of (+)-Tedanolide and (+)-13-Deoxytedanolide Journal of the American Chemical Society 130 48 2008, p. 16407-16416.
Julian, L. D, Z. Wang, T. Bostick, S. Caille, R. Choi, M. DeGraffenreid, Y. Di, X. He, R. W. Hungate, J. C. Jaen, J. Liu, M. Monshouwer, D. McMinn, Y. Rew, A. Sudom, D. Sun, H. Tu, S. Ursu, N. Walker, X. Yan, Q. Ye, and J. P. Powers Discovery of Novel, Potent Benzamide Inhibitors of 11-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex vivo Model Journal of Medicinal Chemistry 51 13 2008, p. 3953-3960.
DeGraffenreid, M, S. Bennett, S. Caille, F. Gonzalez-Lopez de Turiso, R. W. Hungate, L. D. Julian, J. Kaizerman, D. L. McMinn, Y. Rew, D. Sun, X. Yan, and J. P. Powers An Efficient and Scalable One-Pot Double Michael Addition-Dieckmann Cyclization for the Synthesis of 4,4-Disubstituted Cyclohexane ß-Keto Esters Journal of the American Chemical Society 72 19 2007, p. 7455-7458.
Julian, L. D, J. S. Newcom, and W. R. Rousch Total Synthesis of (+)-13-Deoxytedanolide Journal of American Chemical Society 127 17 2005, p. 6186-6187.