Additional Campus Affiliations
Affiliate, Chemical and Biomolecular Engineering
Professor, Electrical and Computer Engineering
Christy Landes earned a B.S. in chemistry from George Mason University in 1998, and her Ph.D. was awarded from the Georgia Institute of Technology in 2003 under the direction of Mostafa El-Sayed. After postdoctoral positions at the University of Oregon and the University of Texas at Austin, she began her independent career at the University of Houston in 2006. In 2009 she moved to Rice University, where she rose through the ranks to become the Kenneth S. Pitzer-Schlumberger Chair of Chemistry. In 2023, she joined the University of Illinois Urbana-Champaign.
Physical, analytical and materials chemistry; predictive separations; spectro-electrochemistry; protein dynamics at interfaces; imaging and signal processing; single-molecule spectroscopy.
As experimental physical chemists, the overall goal of our research is to understand the frequently complex structure-function relationships in biological processes and to use this information to inspire innovation for materials design.
Practical goals in materials engineering include minimal cost, maximum efficiency, and optimized longevity. As our experimental and theoretical methods to study nature’s molecular-scale design principles have improved, we have begun to understand that one reason nature can be so successful is that her engineering strategy often differs from ours. Whereas humans usually design materials with a single, well-defined function, nature often acts through redundant or degenerate channels that are individually not as efficient, but collectively, and in the face of damage or wear, outperform their synthetic cousins.
Obtaining clues from the biological structure-function interplay presents challenges for theory, experiment, and data analysis. When we study one molecule at a time, we eliminate ensemble averaging, thereby accessing any underlying conformational complexity. However, we must develop new methods to increase information content in the resulting low signal-to-noise single-molecule data. Thus, our research efforts have focused on three specific objectives necessary to achieve the overall goal discussed above:
1) Develop experimental data acquisition and analysis methods to optimize information retrieval in single-molecule and single-particle spectroscopies.
2) Characterize biological examples of heterogeneous structure-function relationships.
3) Identify, understand, and optimize heterogeneous structure-function relationships in synthetic systems.
Awards and Honors
2020: Award for Special Creativity, National Science Foundation
2019: Kavli Fellow, U. S. National Academy of Sciences
2016: Early Career Award in Experimental Physical Chemistry, Division of Physical Chemistry, American Chemical Society
2011: NSF CAREER Award
Hanyi Duan, Zhenyang Jia, Maham Liaqat, Matthew D Mellor, Haiyan Tan, Mu-Ping Nieh, Yao Lin, Stephan Link, Christy F Landes, Jie He (2023) ACS Nano Site-Specific Chemistry on Gold Nanorods: Curvature-Guided Surface Dewetting and Supracolloidal Polymerization
Dongyu Fan, Shahryar Ramezani Bajgiran, Farshad Safi Samghabadi, Chayan Dutta, Emil Gillett, Peter J Rossky, Jacinta C Conrad, Amanda B Marciel, Christy F Landes (2023) Langmuir Imaging Heterogeneous 3D Dynamics of Individual Solutes in a Polyelectrolyte Brush
Alexander Al-Zubeidi, Yufei Wang, Jiamu Lin, Charlotte Flatebo, Christy F Landes, Hang Ren, Stephan Link (2023) The Journal of Physical Chemistry Letters d-Band Holes React at the Tips of Gold Nanorods
Anastasiia Misiura, Hao Shen, Lawrence Tauzin, Chayan Dutta, Logan DC Bishop, Nicole C Carrejo, Jorge Zepeda O, Shahryar Ramezani, Nicholas A Moringo, Amanda B Marciel, Peter J Rossky, Christy F Landes (2021) Analytical Chemistry Single-molecule dynamics reflect IgG conformational changes associated with ion-exchange chromatography
Nicholas A Moringo, Logan DC Bishop, Hao Shen, Anastasiia Misiura, Nicole C Carrejo, Rashad Baiyasi, Wenxiao Wang, Fan Ye, Jacob T Robinson, Christy F Landes (2019) Proceedings of the National Academy of Sciences A mechanistic examination of salting out in protein–polymer membrane interactions
Al-Zubeidi, A., Wang, Y., Lin, J., Flatebo, C., Landes, C. F., Ren, H., & Link, S. (Accepted/In press). d-Band Holes React at the Tips of Gold Nanorods. Journal of Physical Chemistry Letters, 14(23), 5297-5304. https://doi.org/10.1021/acs.jpclett.3c00997
Al-Zubeidi, A., Ostovar, B., Carlin, C. C., Li, B. C., Lee, S. A., Chiang, W. Y., Gross, N., Dutta, S., Misiura, A., Searles, E. K., Chakraborty, A., Roberts, S. T., Dionne, J. A., Rossky, P. J., Landes, C. F., & Link, S. (2023). Mechanism for plasmon-generated solvated electrons. Proceedings of the National Academy of Sciences of the United States of America, 120(3), Article e2217035120. https://doi.org/10.1073/pnas.2217035120
Duan, H., Jia, Z., Liaqat, M., Mellor, M. D., Tan, H., Nieh, M-P., Lin, Y., Link, S., Landes, C. F., & He, J. (2023). Site-Specific Chemistry on Gold Nanorods: Curvature-Guided Surface Dewetting and Supracolloidal Polymerization. ACS Nano, 17(13), 12788-12797. Advance online publication. https://doi.org/10.1021/acsnano.3c03929
Fan, D., Bajgiran, S. R., Samghabadi, F. S., Dutta, C., Gillett, E., Rossky, P. J., Conrad, J. C., Marciel, A. B., & Landes, C. F. (2023). Imaging Heterogeneous 3D Dynamics of Individual Solutes in a Polyelectrolyte Brush. Langmuir, 39(24), 8532-8539. https://doi.org/10.1021/acs.langmuir.3c00868
Gross, N., Kuhs, C. T., Ostovar, B., Chiang, W. Y., Wilson, K. S., Volek, T. S., Faitz, Z. M., Carlin, C. C., Dionne, J. A., Zanni, M. T., Gruebele, M., Roberts, S. T., Link, S., & Landes, C. F. (2023). Progress and Prospects in Optical Ultrafast Microscopy in the Visible Spectral Region: Transient Absorption and Two-Dimensional Microscopy. Journal of Physical Chemistry C, 127(30), 14557-14586. https://doi.org/10.1021/acs.jpcc.3c02091