Chemical Biology

Recent advances in chemistry, molecular biology, and biophysics are presenting us with spectacular opportunities both to increase our understanding of biological systems at the molecular level and to attack biomedical problems.

For individual faculty research in Chemical Biology, please see the Chemical Biology faculty page. For the annual Chemical Biology Area Research Conference (CBARC), please see the CBARC page.

Chemical BiologyChemists are addressing problems in biochemistry, pharmacology, cell biology, structural biology, and medicine by designing and constructing small molecules as spectroscopic probes, functional analogues, and diagnostic and therapeutic agents. In turn, the methods of molecular biology, biomimetics and genetics are providing approaches and solutions to chemical problems, by mutagenesis to probe the mechanisms of enzymatic reactions, by production of large quantities of pure proteins for spectroscopic and biophysical studies, and by convenient generation of structural diversity. The application of computational methods to complex biological systems is having a major impact on the way chemical tools are being used in biology, through the creation of computer-based models of small molecules and macromolecules whose interaction energies and dynamics can then be measured.

Clearly, the traditional boundary between chemistry and biology has become nearly seamless. Those researchers best equipped to make major advances in biology and medicine will be those able to apply an integrated combination of chemical, structural, biophysical, computational, and molecular biological methods to problems in these areas. However, the system for training researchers in the various areas of chemistry (analytical, inorganic, organic, and physical) has generally maintained a traditional, single-disciplinary focus. Although some investigators have broadened their selection of research problems or techniques, what is often lacking at the level of research training is an organized and integrated program that exposes young scientists to the full spectrum of systems and the wide array of concepts, techniques and methods that they will need to master in order to drive the future advances in chemistry, biology, human health, and the modern biotechnology industry.

To meet this critical need for researchers in the Department of Chemistry at the University of Illinois, in 1998 we created a new area of Chemical Biology to complement the traditional areas. The Chemical Biology area offers a flexible program of graduate study and research, with a diverse array of research opportunities in all aspects of chemical studies of biological systems in the laboratories of more than 30 faculty in the Department of Chemistry. The Chemical Biology area also provides a multidisciplinary seminar program, and area faculty have recently established core lecture and laboratory courses in the fundamental aspects of our discipline. As with all other chemistry areas, our graduate students have the opportunity to collaborate with groups in other departments (e.g. Biochemistry, Microbiology, and Physics). The Chemical Biology area also offers fellowship support for exceptional applicants.

Representative Research Areas and Topics in Chemical Biology

Analytical Methods

ultramicro analysis · surface spectroscopy · neuropeptides · pressure effects on protein dynamics · carbohydrate analysis · protein mass spectrometry · scanning tunneling microscopy · atomic force microscopy · surface plasmon resonance spectrometry

Molecular Biology, Biochemistry & Regulation

protein design and engineering · regulation of enzymes · RNA processing · heme proteins · lipoproteins · membranes and membrane-bound enzymes · DNA-cleaving enzymes · Vitamin B12enzymes · transcription · synapse formation · protein folding and modification

Organic & Inorganic Chemical Synthesis, Pharmacology

carbohydrate and nucleic acid synthesis · porphyrin systems · metal complexes · biosynthesis · molecular devices · isolation and structure determination · antiviral agents · antibiotics · molecular recognition · biomimetic chemistry · combinatorial chemistry · dendrimers · self-assembling systems · synthetic methods · asymmetric catalysis · total synthesis · amino acid and peptide synthesis

Structure, Spectroscopy & Imaging

X-ray crystallography of proteins and DNA · NMR spectroscopy of protein structure and dynamics · NMR imaging · NMR contrast agents · fluorescence dynamics · laser-induced protein dynamics · 3-D optical imaging of biostructures

Theoretical Modeling, Structure Prediction & Design

computational modeling · protein structure prediction · design of inhibitors, intercalators, agonists, and antagonists · chemical and spectroscopic probes · cell receptor dynamics · protein folding theory

For details about specific areas of research, refer to the Chemical Biology faculty page.

NIH Chemistry-Biology Interface Training Program (CBITP)

The NIH-funded CBITP is a training program for graduate students in chemistry and other departments whose research interests are at the chemistry-biology interface. Formal participation in the CBITP by first-year graduate students is by invitation, based on interviews during the previous spring semester. More information about the CBITP is available at the CBI Training Program website.

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