Liviu M. Mirica

 Liviu Mirica

Contact Information

Department of Chemistry
University of Illinois
601 S. Goodwin Avenue
A442 CLSL, MC-712
Urbana, IL 61801
William H. and Janet G. Lycan Professor of Chemistry
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Biography

Professor Liviu M. Mirica received his B.S. degree in Chemistry from California Institute of Technology in 1999, and his Ph.D. in Chemistry from Stanford University in 2005. After working as an NIH postdoctoral fellow at University of California, Berkeley, in 2008 he started his independent career in the Department of Chemistry at Washington University in St. Louis. In January 2019 he will join the faculty of the Department of Chemistry at the University of Illinois.

Research Interests

  • synthetic inorganic and organometallic chemistry applied to renewable energy catalysis and oxidative organic transformations; development of bifunctional therapeutic and diagnostic agents for amyloid peptide disorders such as Alzheimer’s disease; study of the role of transition metal ions in neurodegenerative diseases

Research Description

Our group’s research program falls under the general areas of synthetic inorganic and organometallic chemistry and chemical biology. The pursued research projects include the synthesis and characterization of novel transition metal complexes that can mediate multi-electron redox processes relevant to energy applications and oxidative organic transformations. Targeted reactions include the aerobic oxidative C-C coupling of hydrocarbons catalyzed by high-valent late transition metal complexes, and catalytic oxidative C-H functionalization and C-C/C-heteroatom bond formation reactions using green oxidants. In addition, we are investigating the role of transition metal ions in the aggregation of amyloid β (Aβ) peptides in Alzheimer’s disease (AD), and we develop bifunctional metal-binding and metal-containing bifunctional compounds as potential therapeutic and diagnostic agents for AD.

Distinctions / Awards

  • BK21–KAIST Lectureship Award, Korea Advanced Institute of Science and Technology, 2017
  • Innovation Award, St. Louis Academy of Sciences, 2017
  • Saint Louis Award, ACS St. Louis Section, 2016
  • Organometallics Young Investigator Fellowship, ACS Division of Organic Chemistry, 2014
  • Saltman Lectureship, Metals in Biology Gordon Research Conference, 2014
  • NSF CAREER Award, 2013
  • Undergraduate Research Mentor of the Year Award, Washington University, 2012
  • Alfred P. Sloan Foundation Research Fellowship, 2012
  • Outstanding Faculty Member Nominee, Freshman Class Council & First Year Center, 2011
  • Sony Electronics Scholarship Award for Excellence in Teaching, Washington University, 2011
  • Ralph E. Powe Junior Faculty Award, Oak Ridge Associated Universities, 2010-2011
  • NIH–NRSA Postdoctoral Fellowship, 2007-2008
  • Young Investigator Award, Division of Inorganic Chemistry, ACS, 2006
  • Franklin Veatch Memorial Fellowship, Stanford University, 2004-2005
  • Stanford Graduate Fellowship, Stanford University, 1999-2003
  • Taube Prize, Stanford University, 1999
  • Merck Index Award for Excellence in Chemistry, California Institute of Technology, 1999
  • Carnation Merit Award, California Institute of Technology, 1997-1998
  • Silver Medal, International Chemistry Olympiad, Beijing, China, 1995
  • Gold Medal, International Chemistry Olympiad, Oslo, Norway, 1994

Selected Publications

Journal Articles

Rana, M, H. J. Cho, T. K. Roy, L. M. Mirica, and A. K. Sharma Azo-dyes based small bifunctional molecules for metal chelation and controlling amyloid formation Inorganica Chimica Acta 471 2018, p. 419-429.
Tang, F, S. Park, N. P. Rath, and L. M. Mirica Electronic versus Steric Effects of Pyridinophane Ligands in Pd(III) Complexes Dalton Transactions 47 4 2018, p. 1151-1158.
Bandara, N, A. K. Sharma, S. Krieger, J. W. Schultz, B. H. Han, B. E. Rogers, and L. M. Mirica Evaluation of 64Cu-Based Radiopharmaceuticals that Target Aβ Peptide Aggregates as Diagnostic Tools for Alzheimer’s Disease Journal of the Americcan Chemical Society 139 36 2017, p. 12550–12558.
Wessel, A. J, J. W. Schultz, F. Tang, H. Duan, and L. M. Mirica Improved Synthesis of Symmetrically & Asymmetrically N-Substituted Pyridinophane Derivatives Organic & Biomolecular Chemistry 46 15 2017, p. 9923-9932.
Waston, M. B, N. P. Rath, and L. M. Mirica Oxidative C-C Bond Formation Reactivity of Organometallic Ni(II), Ni(III), and Ni(IV) Complexes Journal of the Americcan Chemical Society 139 1 2017, p. 35-38.
Sharma, A. K, J. W. Schultz, J. T. Prior, N. P. Rath, and L. M. Mirica The Coordination Chemistry of Bifunctional Chemical Agents Designed for Applications in 64Cu PET Imaging for Alzheimer’s Disease Inorganic Chemistry 56 22 2017, p. 13801-13814.
Cascella, B, S. G. Lee, S. Singh, J. M. Jez, and L. M. Mirica The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A Chemical Communications 53 13 2017, p. 2174-2177.
Zhou, W, S. Zheng, J. W. Schultz, N. P. Rath, and L. M. Mirica Aromatic Cyanoalkylation through Double C-H Activation Mediated by Ni(III) Journal of the American Chemical Society 138 18 2016, p. 5777-5780.
Schultz, J. W, K. Fuchigami, B. Zheng, N. P. Rath, and L. M. Mirica Isolated Organometallic Nickel(III) and Nickel(IV) Complexes Relevant to Carbon-Carbon Bond Formation Reactions Journal of the Americcan Chemical Society 138 39 2016, p. 12928-12934.
Zhou, W, J. W. Schultz, N. P. Rath, and L. M. Mirica Aromatic Methoxylation and Hydroxylation by Organometallic High-Valent Nickel Complexes Journal of the American Chemical Society 137 24 2015, p. 7604-7607.
Tang, F, N. P. Rath, and L. M. Mirica Stable Bis(trifluoromethyl)Nickel(III) Complexes Chemical Communications 51 15 2015, p. 3113-3116.
Qu, F, J. R. Khusnutdinova, N. P. Rath, and L. M. Mirica Dioxygen Activation by an Organometallic Pd(II) Precursor: Formation of a Pd(IV)-OH Complex and Its C-O Bond Formation Reactivity Chemical Communications 50 23 2014, p. 3036-3039.
Zheng, B, F. Tang, J. Luo, J. W. Schultz, N. P. Rath, and L. M. Mirica Organometallic Nickel(III) Complexes Relevant to Cross-Coupling and Carbon-Heteroatom Bond Formation Reactions Journal of the American Chemical Society 136 17 2014, p. 6499-6504.
Zhang, Y, D. L. Rempel, J. Zhang, A. K. Sharma, L. M. Mirica, and M. L. Gross Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation Proceedings of the National Academy of Sciences, U.S.A. 110 36 2013, p. 14604-14609.
Mirica, L. M, and J. R. Khusnutdinova Structure and Electronic Properties of Pd(III) Complexes Coordination Chemistry Reviews 257 2 2013, p. 299-314.
Sharma, A. K, S. T. Pavlova, J. Kim, D. Finkelstein, N. J. Hawco, N. P. Rath, J. Kim, and L. M. Mirica Bifunctional Metal-Binding Compounds for Controlling the Metal-Mediated Aggregation of the Aβ42 Peptide Journal of the American Chemical Society 134 15 2012, p. 6625-6636.
Khusnutdinova, J. R, N. P. Rath, and L. M. Mirica The Aerobic Oxidation of a Pd(II) Dimethyl Complex Leads to Selective Ethane Elimination from a Pd(III) Intermediate Journal of the American Chemical Society 134 4 2012, p. 2414-2422.
Khusnutdinova, J. R, N. P. Rath, and L. M. Mirica Dinuclear Pd(III) Complexes with a Single Unsupported Bridging Halide Ligand: Reversible Formation from Mononuclear Pd(II) or Pd(IV) Precursors Angewandte Chemi International Edition 50 24 2011, p. 5532-5536.
Khusnutdinova, J. R, N. P. Rath, and L. M. Mirica Stable Mononuclear Organometallic Pd(III) Complexes and Their C-C Bond Formation Reactivity Journal of the American Chemical Society 132 21 2010, p. 7303-7305.