Chemical Biology Faculty

Martin D. Burke Synthesis and study of small molecules with protein-like functions; molecular prosthetics; synthesis of complex natural products; iterative cross-coupling; MIDA boronates
Jefferson Chan Development of chemical probes for sensing and biological imaging of disease states; synthesis of
small molecules and nanomaterials to modulate biology with light  
Martin Gruebele In vitro, in cell, and in vivo protein folding; protein-RNA interactions; protein-protein interaction dynamics
Hee-Sun Han Dissecting complex molecular networks in healthy/diseased tissues; single virus genomics; single cell transcriptomics; in vitro/in vivo imaging; quantum dots; microfluidics; high-throughput technologies
Paul J. Hergenrother Use of small molecules to identify and define novel targets for the treatment of cancer, neurodegeneration, and drug-resistant bacteria 
Yi Lu Metalloprotein design based on proteomics and computational biology; nucleic acid sensors and therapeutics; DNA nanomaterials
Zaida (Zan) Luthey-Schulten Simulations of in vivo stochastic processes in single cells and colonies using GPUs; physics of metabolic networks; evolution of translation; dynamical networks of protein-RNA interactions; statistical mechanics of the genome and DNA replication
Liviu M. Mirica Development of bifunctional therapeutic and diagnostic agents for amyloid peptide disorders such as Alzheimer’s disease; study of the role of transition metal ions in neurodegenerative diseases
Douglas A. Mitchell Natural product chemical biology; mechanistic enzymology; structure-function studies of complex small molecules; bioinformatic and bioorganic methodology to accelerate biomedical discovery 
Eric Oldfield Drug discovery and NMR/X-ray
Lisa Olshansky Switchable artificial metalloproteins for the investigation of enzyme mechanism; application to renewable energy conversion and in the development of targeted therapeutics  
Chad M. Rienstra NMR methods for biomolecular structure and function; applications to Parkinson’s disease, systemic amyloidosis, and drug-sterol interactions 
Scott K. Silverman DNA as an enzyme
Jonathan V. Sweedler Neurochemistry: the characterization of unusual neurotransmitters and neuromodulators and the determination of their function  
Wilfred A. van der Donk Antibiotic biosynthesis; combinatorial chemistry of phosphonates; enzymology
Steven C. Zimmerman Small-molecule therapeutic agents that target DNA and RNA; development of chemical catalysts for chemical biology; drug and cellular delivery agents; biomaterials; nanomedicine 


Other Faculty with Interests in Chemical Biology:

Raven H. Huang (affiliate faculty) Structural biology
Mary L. Kraft (affiliate faculty) Biomembrane surface science
Deborah E. Leckband Biological adhesion
Susan A. Martinis RNA-protein structure/function
Catherine J. Murphy Biophysical chemistry
Satish K. Nair (affiliate faculty) Structural biology
Stephen G. Sligar (emeritus faculty) Nanobiotechnology and drug discovery
Huimin Zhao (affiliate faculty) Synthetic biology and natural product synthesis