PROFESSOR | INTERESTS |
---|---|
Martin D. Burke | Synthesis and study of small molecules with protein-like functions; molecular prosthetics; synthesis of complex natural products; iterative cross-coupling; MIDA boronates |
Jefferson Chan |
Advanced imaging agents for neurological disorders and cancer; synthesis of activity-based sensing probes to discover new mechanisms of premature aging; chemically responsive platforms for on-demand and site-selective drug delivery |
Martin Gruebele | In vitro, in cell, and in vivo protein folding; protein-RNA interactions; protein-protein interaction dynamics |
Hee-Sun Han | Dissecting complex molecular networks in healthy/diseased tissues; single virus genomics; single cell transcriptomics; in vitro/in vivo imaging; quantum dots; microfluidics; high-throughput technologies |
Paul J. Hergenrother | Use of small molecules to identify and define novel targets for the treatment of cancer, neurodegeneration, and drug-resistant bacteria |
Zaida (Zan) Luthey-Schulten | Simulations of in vivo stochastic processes in single cells and colonies using GPUs; physics of metabolic networks; evolution of translation; dynamical networks of protein-RNA interactions; statistical mechanics of the genome and DNA replication |
Anastasia C. Manesis | Bioinorganic chemistry of metalloproteins; structural and mechanistic studies of diheme and multiheme enzymes as it relates to O2 activation chemistry; bioinformatics-guided approaches to the identification of novel metallocofactors within unexplored protein superfamilies; metalloenzyme catalysis; microbial oxidative stress response; protein engineering. |
Angad P. Mehta | Synthetic and molecular engineering platforms to: (i) recapitulate eukaryotic cell evolution, particularly, organelle evolution, (ii) develop synthetic tools for genome editing and (iii) develop vaccine candidates by constructing synthetic biochemical pathways |
Liviu M. Mirica | Development of bifunctional therapeutic and diagnostic agents for amyloid peptide disorders such as Alzheimer’s disease; study of the role of transition metal ions in neurodegenerative diseases |
Douglas A. Mitchell | Natural product chemical biology; mechanistic enzymology; structure-function studies of complex small molecules; bioinformatic and bioorganic methodology to accelerate biomedical discovery |
Eric Oldfield | Drug discovery and NMR/X-ray |
Lisa Olshansky | Switchable artificial metalloproteins for the investigation of enzyme mechanism; application to renewable energy conversion and in the development of targeted therapeutics |
Scott K. Silverman | DNA as an enzyme |
Jonathan V. Sweedler | Neurochemistry: the characterization of unusual neurotransmitters and neuromodulators and the determination of their function |
Wilfred A. van der Donk | Antibiotic biosynthesis; combinatorial chemistry of phosphonates; enzymology |
Other Faculty with Interests in Chemical Biology:
PROFESSOR | INTERESTS |
---|---|
Raven H. Huang (faculty affiliate) | Structural biology |
Mary L. Kraft (faculty affiliate) | Biomembrane surface science |
Deborah E. Leckband | Biological adhesion |
Susan A. Martinis (faculty affiliate) | RNA-protein structure/function |
Catherine J. Murphy | Biophysical chemistry |
Satish K. Nair (faculty affiliate) | Structural biology |
Stephen G. Sligar (emeritus faculty) | Nanobiotechnology and drug discovery |
Huimin Zhao (faculty affiliate) | Synthetic biology and natural product synthesis |