Contact Information
University of Illinois
419 Roger Adams Lab B-4
600 S Mathews Ave
Urbana, IL 61801
Additional Campus Affiliations
Professor, Biochemistry
Professor, Center for Biophysics and Quantitative Biology
Research Interests
Research Topics
Bioinformatics, Drug Discovery, Enzymology, Host-Pathogen Interactions, Molecular Evolution, Protein Synthesis, Protein-Nucleic Acid Interactions, RNA Biology, Toxins
Education
B.S. and M.S. 1986 Nankai University
Ph.D. 1995 University of Washington
Postdoc. 1996-99 Harvard University
Recent Publications
Fatma, S., Chakravarti, A., Zeng, X., & Huang, R. H. (2021). Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger. Nature communications, 12(1), [6381]. https://doi.org/10.1038/s41467-021-26738-2
Huang, R. H. (2019). Ribotoxins Kill Cells by Chopping off the Head of tRNAs. Structure, 27(11), 1613-1614. https://doi.org/10.1016/j.str.2019.10.009
Castelle, C. J., Brown, C. T., Anantharaman, K., Probst, A. J., Huang, R. H., & Banfield, J. F. (2018). Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations. Nature Reviews Microbiology, 16(10), 629-645. https://doi.org/10.1038/s41579-018-0076-2
Chakravarti, A., Selvadurai, K., Shahoei, R., Lee, H., Fatma, S., Tajkhorshid, E., & Huang, R. H. (2018). Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin. Journal of Biological Chemistry, 293(36), 14122-14133. https://doi.org/10.1074/jbc.RA118.003998
Keller, P., Freund, I., Marchand, V., Bec, G., Huang, R., Motorin, Y., Eigenbrod, T., Dalpke, A., & Helm, M. (2018). Double methylation of tRNA-U54 to 2-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7. Nucleic acids research, 46(18), 9764-9775. https://doi.org/10.1093/nar/gky644