Contact Information
University of Illinois
419 Roger Adams Lab B-4
600 S Mathews Ave
Urbana, IL 61801
Research Interests
Research Topics
Bioinformatics, Drug Discovery, Enzymology, Host-Pathogen Interactions, Molecular Evolution, Protein Synthesis, Protein-Nucleic Acid Interactions, RNA Biology, Toxins
Education
B.S. and M.S. 1986 Nankai University
Ph.D. 1995 University of Washington
Postdoc. 1996-99 Harvard University
Additional Campus Affiliations
Professor, Biochemistry
Professor, Center for Biophysics and Quantitative Biology
Recent Publications
Tian, Y., Li, Q., Fatma, S., Jiang, J., Jin, H., Zeng, F., & Huang, R. H. (2026). Molecular and structural basis of a subfamily of PrfH rescuing both the damaged and intact ribosomes stalled in translation. Science Advances, 12(4), Article eaea7378. https://doi.org/10.1126/sciadv.aea7378
Tian, Y., Zeng, F., Raybarman, A., Fatma, S., Carruthers, A., Li, Q., & Huang, R. H. (2022). Sequential rescue and repair of stalled and damaged ribosome by bacterial PrfH and RtcB. Proceedings of the National Academy of Sciences of the United States of America, 119(29), Article e2202464119. https://doi.org/10.1073/pnas.2202464119
Fatma, S., Chakravarti, A., Zeng, X., & Huang, R. H. (2021). Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger. Nature communications, 12(1), Article 6381. https://doi.org/10.1038/s41467-021-26738-2
Huang, R. H. (2019). Ribotoxins Kill Cells by Chopping off the Head of tRNAs. Structure, 27(11), 1613-1614. https://doi.org/10.1016/j.str.2019.10.009
Castelle, C. J., Brown, C. T., Anantharaman, K., Probst, A. J., Huang, R. H., & Banfield, J. F. (2018). Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations. Nature Reviews Microbiology, 16(10), 629-645. https://doi.org/10.1038/s41579-018-0076-2