Lisa Olshansky

LEAP Scholar, and Assistant Professor of Chemistry

Biography

Professor Olshansky began her studies at San Diego City College before transferring to UC San Diego and graduating with highest honors in 2009 with a B.S. in Chemistry. She went on to MIT as an NSF and Presidential graduate research fellow, earning a PhD in Inorganic Chemistry in 2015. Following research at UC Irvine as an ACS Irving S. Sigal Postdoctoral Fellow, she joined the faculty at the University of Illinois in 2018.

Research Interests

Bioinspired inorganic chemistry, synthesis of metal complexes capable of undergoing triggered conformational changes, preparation of switchable artificial metalloproteins, applications in biomedical research and renewable energy.

Research Description

Research in the Olshansky lab is focused on mimicking the way that biological systems use structural changes as a vehicle for the interconversion of different forms of energy (e.g. converting binding energy, protein-protein interactions, sunlight, or pH gradients into chemical energy). This mechanistic paradigm is prevalent in biology and represents a powerful means with which to direct energetically demanding reactions without the need for excessive energy input.

We are inspired by the countless enzymatic systems that, upon stimulation, use macromolecular changes to gate reactivity. Biomimetic metallocofactors are prepared both synthetically and through the generation of artificial metalloproteins. In both cases stimulus-responsive conformational changes target changes in metal ion coordination geometry and secondary sphere interactions to affect changes in the intrinsic properties of the metallocofactor (E°', pKa, spin state, substrate activation). In turn, these changes are leveraged to do work, with applications ranging from biomedical imaging and targeted drug delivery to solar fuels production.

We are a multidisciplinary group and use a combination of synthetic, physical and biochemical methods to achieve these goals. Students from all areas are encouraged to apply.

Honors & Awards

2022-2027 Department of Energy Early Career Research Award
2022 San Diego City College Working in Industry Alumni Award
2022-2025 Cottrell Scholar Award
2021-2025 Vallee Scholars Award
2021-2023 Lincoln Excellence for Assistant Professors Award UIUC
2020-2023 Searle Scholars Award
2020-2023 Carver Trust Young Investigator Award
2020-2025 National Institutes of Health Maximizing Investigators' Research Award for Early-Stage Investigators (R35)

Highlighted Publications

Griffin, P. J., Charette, B. J., Burke, J. H., Vura-Weis, J., Schaller, R. D., Gosztola, D. J., & Olshansky, L. (2022). Toward Improved Charge Separation through Conformational Control in Copper Coordination Complexes. Journal of the American Chemical Society, 144(27), 12116-12126. https://doi.org/10.1021/jacs.2c02580

Charette, B. J., Griffin, P. J., Zimmerman, C. M., & Olshansky, L. (Accepted/In press). Conformationally dynamic copper coordination complexes. Dalton Transactions. https://doi.org/10.1039/d2dt00312k

Delucia, A. A., Kelly, K. A., Herrera, K. A., Gray, D. L., & Olshansky, L. (2021). Intramolecular Hydrogen-Bond Interactions Tune Reactivity in Biomimetic Bis(μ-hydroxo)dicobalt Complexes. Inorganic Chemistry, 60(20), 15599-15609. https://doi.org/10.1021/acs.inorgchem.1c02210

Olshansky, L., Huerta-Lavorie, R., Nguyen, A. I., Vallapurackal, J., Furst, A., Tilley, T. D., & Borovik, A. S. (2018). Artificial Metalloproteins Containing Co₄O₄ Cubane Active Sites. Journal of the American Chemical Society, 140(8), 2739-2742. https://doi.org/10.1021/jacs.7b13052

Olshansky, L., Greene, B. L., Finkbeiner, C., Stubbe, J., & Nocera, D. G. (2016). Photochemical Generation of a Tryptophan Radical within the Subunit Interface of Ribonucleotide Reductase. Biochemistry, 55(23), 3234-3240. https://doi.org/10.1021/acs.biochem.6b00292

Olshansky, L., Stubbe, J., & Nocera, D. G. (2016). Charge-Transfer Dynamics at the α/β Subunit Interface of a Photochemical Ribonucleotide Reductase. Journal of the American Chemical Society, 138(4), 1196-1205. https://doi.org/10.1021/jacs.5b09259

Olshansky, L., Pizano, A. A., Wei, Y., Stubbe, J., & Nocera, D. G. (2014). Kinetics of hydrogen atom abstraction from substrate by an active site thiyl radical in ribonucleotide reductase. Journal of the American Chemical Society, 136(46), 16210-16216. https://doi.org/10.1021/ja507313w

Pizano, A. A., Olshansky, L., Holder, P. G., Stubbe, J., & Nocera, D. G. (2013). Modulation of Y₃₅₆ photooxidation in E. coli class Ia ribonucleotide reductase by Y₇₃₁ across the α₂: β₂ interface. Journal of the American Chemical Society, 135(36), 13250-13253. https://doi.org/10.1021/ja405498e

Minnihan, E. C., Ando, N., Brignole, E. J., Olshansky, L., Chittuluru, J., Asturias, F. J., Drennan, C. L., Nocera, D. G., & Stubbe, J. A. (2013). Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3835-3840. https://doi.org/10.1073/pnas.1220691110

Ravichandran, K., Olshansky, L., Nocera, D. G., & Stubbe, J. A. (2020). Subunit Interaction Dynamics of Class Ia Ribonucleotide Reductases: In Search of a Robust Assay. Biochemistry, 59(14), 1442-1453. https://doi.org/10.1021/acs.biochem.0c00001

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