Contact Information
University of Illinois
A326 CLSL, MC-712, Box 58-6
600 South Mathews Avenue
Urbana, IL 61801
Biography
After earning her B.S. in Chemistry from UC San Diego in 2009, Dr. Lisa Olshansky completed her Ph.D. in Chemistry at MIT in 2015 as an NSF Graduate Research and Presidential fellow under the mentorship of Profs. Daniel Nocera and JoAnne Stubbe. She then went on to work with Prof. Andy Borovik at UC Irvine as an ACS Irving S. Sigal Postdoctoral fellow. In 2018, Lisa began her independent career as an Assistant Prof. of Chemistry at the University of Illinois, Urbana-Champaign where her team is working to mimic and exploit mechanisms in which macroscopic structural control is used to control the properties of metal centers. During her early career, Olshansky has been recognized with Searle, Cottrell, and Vallee Scholars awards, Carver Trust and DOE Young Investigator awards, and an NIH Early Stage Investigator award. Olshansky was recently named an NAS Kavli Fellow, received the Paul Saltman Young Investigator Award for her research on Metals in Biology, and was recently named a Camille Dreyfus Teacher-Scholar Awardee. Finally, since joining the faculty at Illinois, Olshansky has spearheaded an initiative called C2 that aims to foster inclusivity and diversity in the School of Chemical Sciences.
Research Interests
Bioinspired inorganic chemistry, synthesis of metal complexes capable of undergoing triggered conformational changes, preparation of switchable artificial metalloproteins, applications in biomedical research and renewable energy.
Research Description
Research in the Olshansky lab is focused on mimicking the way that biological systems use structural changes as a vehicle for the interconversion of different forms of energy (e.g. converting binding energy, protein-protein interactions, sunlight, or pH gradients into chemical energy). This mechanistic paradigm is prevalent in biology and represents a powerful means with which to direct energetically demanding reactions without the need for excessive energy input.
We are inspired by the countless enzymatic systems that, upon stimulation, use macromolecular changes to gate reactivity. Biomimetic metallocofactors are prepared both synthetically and through the generation of artificial metalloproteins. In both cases stimulus-responsive conformational changes target changes in metal ion coordination geometry and secondary sphere interactions to affect changes in the intrinsic properties of the metallocofactor (E°', pKa, spin state, substrate activation). In turn, these changes are leveraged to do work, with applications ranging from biomedical imaging and targeted drug delivery to solar fuels production.
We are a multidisciplinary group and use a combination of synthetic, physical and biochemical methods to achieve these goals. Students from all areas are encouraged to apply.
Awards and Honors
2024 Camille Dreyfus Teacher-Scholar Award
2024 Paul Saltman Young Investigator Award
2023 National Academy of Sciences Kavli Fellow
2022-2027 Department of Energy Early Career Research Award
2022 San Diego City College Working in Industry Alumni Award
2022-2025 Cottrell Scholar Award
2021-2025 Vallee Scholars Award
2021-2023 Lincoln Excellence for Assistant Professors Award UIUC
2020-2023 Searle Scholars Award
2020-2023 Carver Trust Young Investigator Award
2020-2025 National Institutes of Health Maximizing Investigators' Research Award for Early-Stage Investigators (R35)
Additional Campus Affiliations
- Beckman Institute for Advanced Science and Technology
- Center for Biophysics and Quantitative Biology
- Department of Chemical and Biomoelcular Engineering
- Materials Research Laboratory
Highlighted Publications
Khadanand, K. C., Woods, T., & Olshansky, L. (2023). Ligand Modifications Produce Two‐Step Magnetic Switching in a Cobalt(dioxolene) Complex. Angewandte Chemie - International Edition, 62(45), Article e202311790. https://doi.org/10.1002/anie.202311790
Griffin, P. J., & Olshansky, L. (2023). Rapid Electron Transfer Self-Exchange in Conformationally Dynamic Copper Coordination Complexes. Journal of the American Chemical Society, 145(37), 20158-20162. https://doi.org/10.1021/jacs.3c05935
Charette, B. J., King, S. R., Chen, J., Holm, A. R., Malme, J. T., Cook, R. D., Schaller, R. D., Jackson, N. E., & Olshansky, L. (2023). Excited State Dynamics of a Conformationally Fluxional Copper Coordination Complex. Journal of Physical Chemistry A, 127(37), 7747-7755. https://doi.org/10.1021/acs.jpca.3c04269
Griffin, P. J., Dake, M. J., Remolina, A. D., & Olshansky, L. (2023). Conformational Dynamicity in a Copper(II) Coordination Complex. Dalton Transactions, 52(24), 8376-8383. https://doi.org/10.1039/d3dt01213a
Fatima, S., Boggs, D. G., Ali, N., Thompson, P. J., Thielges, M. C., Bridwell-Rabb, J., & Olshansky, L. (2022). Engineering a Conformationally Switchable Artificial Metalloprotein. Journal of the American Chemical Society, 144(47), 21606-21616. https://doi.org/10.1021/jacs.2c08885
Griffin, P. J., Charette, B. J., Burke, J. H., Vura-Weis, J., Schaller, R. D., Gosztola, D. J., & Olshansky, L. (2022). Toward Improved Charge Separation through Conformational Control in Copper Coordination Complexes. Journal of the American Chemical Society, 144(27), 12116-12126. https://doi.org/10.1021/jacs.2c02580
Charette, B. J., Griffin, P. J., Zimmerman, C. M., & Olshansky, L. (2022). Conformationally Dynamic Copper Coordination Complexes. Dalton Transactions, 51(16), 6212-6219. https://doi.org/10.1039/d2dt00312k
Delucia, A. A., Kelly, K. A., Herrera, K. A., Gray, D. L., & Olshansky, L. (2021). Intramolecular Hydrogen-Bond Interactions Tune Reactivity in Biomimetic Bis(μ-hydroxo)dicobalt Complexes. Inorganic Chemistry, 60(20), 15599-15609. https://doi.org/10.1021/acs.inorgchem.1c02210
Recent Publications
DeLucia, A. A., & Olshansky, L. (2024). Carboxylate Shift Dynamics in Biomimetic Co2(μ-OH)2 Complexes. Inorganic Chemistry, 63(2), 1109-1118. https://doi.org/10.1021/acs.inorgchem.3c03470
DeLucia, A. A., KC, K., & Olshansky, L. (2024). Impact of hydrogen-bonding interactions on the properties of biomimetic Co2(μ-OH)2 complexes. Inorganica Chimica Acta, 564, Article 121931. https://doi.org/10.1016/j.ica.2024.121931
Fatima, S., & Olshansky, L. (2024). Conformational control over proton-coupled electron transfer in metalloenzymes. Nature Reviews Chemistry, 8(10), 762-775. https://doi.org/10.1038/s41570-024-00646-7
Fatima, S., Mehrafrooz, B., Boggs, D. G., Ali, N., Singh, S., Thielges, M. C., Bridwell-Rabb, J., Aksimentiev, A., & Olshansky, L. (2024). Conformation-Dependent Hydrogen-Bonding Interactions in a Switchable Artificial Metalloprotein. Biochemistry, 63(16), 2040-2050. https://doi.org/10.1021/acs.biochem.4c00209
Griffin, P. J., & Olshansky, L. (2024). Emergent properties from dynamicity in biomimetic coordination complexes. Trends in Chemistry, 6(8), 424-427. https://doi.org/10.1016/j.trechm.2024.04.010