U.S. researchers have applied synthetic organic chemistry to solve a mystery that has baffled scientists for more than 50 years: how the powerful, naturally occurring antifungal compound amphotericin B interacts with sterols in cell membranes. The work, carried out by biochemist Martin Burke’s group at Illinois, could open the way to reducing amphotericin’s toxic side effects, and to developing new drugs to replace faulty proteins in human cells – as a kind of molecular prosthesis.

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