Researchers in Sweedler and Kelleher research groups developed a new method to perform restricted proteolysis using outer membrane protease T (OmpT) for mass spectrometry-based proteomics. This work has been published in Nature Methods. According to Cong Wu, the first author on the paper, OmpT's narrower substrate specificity than traditional proteases and efficient catalytic activity enable the production of large peptides, beneficial to combinatorial post-translational modification characterization and isoform-specific protein identifications in proteomic studies.