Contact Information
University of Illinois
Noyes Lab 150, Box 2-1, MC-712
600 South Mathews Ave
Urbana, IL 61801
Additional Campus Affiliations
Research Assistant Professor, Beckman Institute
Fellow, National Center of Supercomputing Applications
Research Assistant Professor, School of Chemical Sciences
Biography
Professor Pogorelov received a Diploma in Biomedical Engineering from Bauman Moscow State Technical University in 1995, an M.S. in Mathematics in 1996, and a Ph.D. in Chemical Physics in 2006 (with Zan Luthey-Schulten), both from the University of Illinois at Urbana-Champaign. From 2006 to 2009 he was a postdoctoral research associate in Chemistry Department (with Todd Martinez) and from 2009 to 2012 he was a postdoctoral research associate at the Beckman Institute (with Emad Tajkhorshid) and a Research Scientist at the School of Chemical Sciences. In 2012 he was appointed a Research Assistant Professor and a Senior Research Scientist in charge of scientific computing, where he advises and collaborates with the School’s researchers in the areas of advanced computational chemistry.
Research Description
Physical Chemistry of Complex Cellular Environments
We are physicists, chemists, biologists, and computer scientists, who address pressing questions in molecular biology of the cell signaling in health and disease. We develop computational methods and workflows by combining frameworks of molecular dynamics, quantum chemistry, and molecular evolution with multi-resolution experimental data. Current emphasis is on functional lipids in membrane-associated phenomena, protein folding and interactions in complex environments, and plasma membrane cell signaling.
Recent Publications
Light, T. P., Gomez-Soler, M., Wang, Z., Karl, K., Zapata-Mercado, E., Gehring, M. P., Lechtenberg, B. C., Pogorelov, T. V., Hristova, K., & Pasquale, E. B. (2021). A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain. Journal of Biological Chemistry, 297(1), [100876]. https://doi.org/10.1016/j.jbc.2021.100876
Rickard, M. M., Zhang, Y., Pogorelov, T. V., Pogorelov, T. V., Pogorelov, T. V., Pogorelov, T. V., Gruebele, M., Gruebele, M., Gruebele, M., & Gruebele, M. (2020). Crowding, Sticking, and Partial Folding of GTT WW Domain in a Small Cytoplasm Model. Journal of Physical Chemistry B, 124(23), 4732-4740. https://doi.org/10.1021/acs.jpcb.0c02536
Song, J., Malwal, S. R., Baig, N., Schurig-Briccio, L. A., Gao, Z., Vaidya, G. S., Yang, K., Abutaleb, N. S., Seleem, M. N., Gennis, R. B., Pogorelov, T. V., Oldfield, E., & Feng, X. (2020). Discovery of Prenyltransferase Inhibitors with in Vitro and in Vivo Antibacterial Activity. ACS Infectious Diseases, 6(11), 2979-2993. https://doi.org/10.1021/acsinfecdis.0c00472
Hudson, G. A., Burkhart, B. J., DiCaprio, A. J., Schwalen, C. J., Kille, B., Pogorelov, T. V., & Mitchell, D. A. (2019). Bioinformatic mapping of radical S-adenosylmethionine-dependent ribosomally synthesized and post-translationally modified peptides identifies new Cα, Cβ, and Cγ-linked thioether-containing peptides. Journal of the American Chemical Society, 141(20), 8228-8238. https://doi.org/10.1021/jacs.9b01519
Prigozhin, M. B., Zhang, Y., Schulten, K., Gruebele, M., & Pogorelov, T. V. (2019). Fast pressure-jump all-atom simulations and experiments reveal site-specific protein dehydration-folding dynamics. Proceedings of the National Academy of Sciences of the United States of America, 116(12), 5356-5361. https://doi.org/10.1073/pnas.1814927116