Contact Information
University of Illinois
Noyes Lab 150, Box 2-1, MC-712
600 South Mathews Ave
Urbana, IL 61801
Research Areas
Additional Campus Affiliations
Research Assistant Professor, Beckman Institute
Fellow, National Center of Supercomputing Applications
Research Assistant Professor, School of Chemical Sciences
Research Assistant Professor of Biophysics
Biography
Professor Pogorelov received a Diploma in Biomedical Engineering from Bauman Moscow State Technical University in 1995, an M.S. in Mathematics in 1996, and a Ph.D. in Chemical Physics in 2006 (with Zan Luthey-Schulten), both from the University of Illinois at Urbana-Champaign. From 2006 to 2009 he was a postdoctoral research associate in Chemistry Department (with Todd Martinez) and from 2009 to 2012 he was a postdoctoral research associate at the Beckman Institute (with Emad Tajkhorshid) and a Research Scientist at the School of Chemical Sciences. In 2012 he was appointed a Research Assistant Professor and a Senior Research Scientist in charge of scientific computing, where he advises and collaborates with the School’s researchers in the areas of advanced computational chemistry.
Research Description
Physical Chemistry of Complex Cellular Environments
We are physicists, chemists, biologists, and computer scientists, who address pressing questions in molecular biology and physical chemistry of the cell signaling in health and disease. We develop computational methods and workflows by combining frameworks of molecular dynamics, quantum chemistry, and molecular evolution with multi-resolution experimental data. Current emphasis is on cell signaling, protein dynamics and interactions in complex environments, and functional lipids in membrane-associated phenomena.
Recent Publications
Boob, M. M., Sukenik, S., Gruebele, M., & Pogorelov, T. V. (2023). TMAO: Protecting proteins from feeling the heat. Biophysical journal, 122(7), 1414-1422. https://doi.org/10.1016/j.bpj.2023.03.008
Cheng, K. J., De Lio, A. M., Jain, R., Paul, D., Morrissey, J. H., & Pogorelov, T. V. (2023). Lactadherin’s Multistate Binding Predicts Stable Membrane-Bound Conformations of Factors V and VIII’s C Domains. Biochemistry, 62(20), 3020-3032. https://doi.org/10.1021/acs.biochem.3c00274
Della Ripa, L. A., Courtney, J. M., Phinney, S. M., Borcik, C. G., Burke, M. D., Rienstra, C., & Pogorelov, T. V. (2023). Segmental Dynamics of Membranous Cholesterol are Coupled. Journal of the American Chemical Society, 145(28), 15043-15048. https://doi.org/10.1021/jacs.3c01775
Maji, A., Soutar, C. P., Zhang, J., Lewandowska, A., Uno, B. E., Yan, S., Shelke, Y., Murhade, G., Nimerovsky, E., Borcik, C. G., Arango, A. S., Lange, J. D., Marin-Toledo, J. P., Lyu, Y., Bailey, K. L., Roady, P. J., Holler, J. T., Khandelwal, A., SantaMaria, A. M., ... Burke, M. D. (2023). Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Nature, 623(7989), 1079-1085. https://doi.org/10.1038/s41586-023-06710-4
McKenzie, D. M., Wirth, D., Pogorelov, T. V., & Hristova, K. (2023). Utility of FRET in studies of membrane protein oligomerization: The concept of the effective dissociation constant. Biophysical journal, 122(20), 4113-4120. https://doi.org/10.1016/j.bpj.2023.09.011