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College of Liberal Arts & Sciences Department of Chemistry

Rohit Bhargava

Profile picture for Rohit Bhargava

Contact Information

405 N. Mathews Ave
Urbana, IL 61801
Founder Professor of Bioengineering, and Faculty Affiliate in Chemistry

Biography

Rohit Bhargava is a Professor in Bioengineering, Grainger Distinguished Chair in Engineering and serves as the Phillip and Ann Sharp Director of the Cancer Center at Illinois. Rohit graduated with a dual-degree B.Tech. (1996) from the Indian Institute of Technology, New Delhi and received a doctoral degree from Case Western Reserve University (2000) and held positions at the National Institutes of Health after graduation. He has been at Illinois as Assistant (2005-2011), Associate (2011-2012) and Full (2012-) Professor since. Rohit is widely recognized for his research on chemical imaging and advances in theory, instrumentation, and applications in cancer pathology. Current work in chemical imaging in his laboratory focuses on theoretical modeling that can push the limits of speed and quality of infrared spectroscopic imaging as well as its application in several novel areas. In particular,  Rohit’s group aims to recognize and subtype cancer by its underlying molecular characteristics, by chemical imaging and application of machine learning, ultimately allowing for better treatment of patients. His innovative teaching and mentoring has been consistently recognized by the success of his students. He conceived and currently directs of the Tissue Microenvironment training program supported by a T32 grant from the NIH. Rohit has also served to connect the research community in new and exciting ways to take on basic science and engineering questions that surround cancer. He was the first assistant professor hired into Illinois’ Bioengineering Department and played a key role in its development. He proposed the Cancer Center at Illinois - a basic science center at the convergence of engineering and oncology - and continues to serve as its Director.

Research Description

The Bhargava group develops and uses chemical imaging technology to detect, diagnose and understand tissue structure, especially related to cancer. A major research theme is the development of novel chemical imaging instrumentation to extend the speed, fidelity and usability of chemical imaging. A second is to use chemical imaging to understand biological processes, especially related to human diseases. Finally, a third area is to develop theory and artificial intelligence methods to use chemical imaging data effectively. Applications include clinical translation of chemical imaging for digital pathology and use of microfabrication techniques to recreate tumors and their microenvironments.

Recent Publications

Chang, C. W., Bale, A., Bhargava, R., & Harley, B. A. C. (2025). Glioblastoma drives protease-independent extracellular matrix invasion of microglia. Materials Today Bio, 31, Article 101475. https://doi.org/10.1016/j.mtbio.2025.101475

Edmonds, H., Mukherjee, S. S., Holcombe, B., Yeh, K., Bhargava, R., & Ghosh, A. (2025). Quantification of Protein Secondary Structures from Discrete Frequency Infrared Images Using Machine Learning. Applied Spectroscopy. Advance online publication. https://doi.org/10.1177/00037028251325553

Hur, S. W., Sengupta, S., Kwon, M., Manoharaan, R., Anastasio, M., & Bhargava, R. (2025). Single-shot quantitative phase gradient microscopy using physics-based untrained neural network phase retrieval. In Y. Liu, & Y. Park (Eds.), Quantitative Phase Imaging XI Article 1332905 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13329). SPIE. https://doi.org/10.1117/12.3043703

Kim, J., Tian, Y., Qiao, G., Villarta, J. A., Zhao, F., He, A., Ho, R. J., Liu, H., Bhargava, R., & Zhang, Y. (2025). Endoscopic Fourier-transform infrared spectroscopy through a fiber microprobe. Review of Scientific Instruments, 96(3), Article 033702. https://doi.org/10.1063/5.0233920

Wu, T., Thornburg, Z. R., Tan, K., Kenkel, S., Boppart, S. A., Bhargava, R., & Luthey-Schulten, Z. (2025). Visualizing Cell Structures with Minecraft. The Biophysicist, 6(1). Advance online publication. https://doi.org/10.35459/tbp.2024.000275

View all publications on Illinois Experts

College of Liberal Arts & Sciences Department of Chemistry

505 South Mathews Avenue

Urbana, IL 61801

(217) 333-5071

Email: chemistry@illinois.edu

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