Contact Information
1304 W Springfield Ave
Urbana, IL 61801
Research Areas
Biography
Dr. Xing Wang is a nucleic acids biochemist, structural DNA nanotechnologist, and molecular biologist at UIUC. He received a Ph.D. in Chemistry from New York University (2009). He then did his postdoctoral training at Princeton University to explore novel functions of synthetic RNAs in genome editing (2013). Before joining UIUC, Dr. Wang was an Assistant Professor in the Department of Chemistry and Chemical Biology and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute (2014-2019).
Research Interests
Dr. Wang’s Nucleic Acids Programming Lab is focused on the design and synthesis of functional DNA/RNA aptamer, nanostructure and nano-device, and on the exploration of their applications in chemistry, engineering, biology, and disease diagnosis and treatment.
Research Description
Biochemistry and Nanotechnology
Dr. Wang's Nucleic Acids Programming Lab (NAPL) is currently focused on the new biotechnology development, design and synthesis of functional DNA/RNA aptamers, nanostructures and nanodevices, and on the exploration of their applications in energy harvesting, basic biology, biosensing, and biomedicine.
Dr. Wang is the inventor of the technology called Pattern-recognition Enabled Sensing and Therapeutics (PEST), that utilizes designer DNA nanostructures (DDN) to create pathogen sensors and inhibitors.
Education
Ph.D. in Chemistry, New York University
Highlighted Publications
Kwon, P. S., Ren, S., Kwon, S. J., Kizer, M. E., Kuo, L., Xie, M., Zhu, D., Zhou, F., Zhang, F., Kim, D., Fraser, K., Kramer, L. D., Seeman, N. C., Dordick, J. S., Linhardt, R. J., Chao, J., & Wang, X. (2020). Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition. Nature Chemistry, 12(1), 26-35. https://doi.org/10.1038/s41557-019-0369-8
Kizer, M. E., Linhardt, R. J., Chandrasekaran, A. R., & Wang, X. (2019). A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures. Small, 15(26), [1805386]. https://doi.org/10.1002/smll.201805386
Wang, X., Chandrasekaran, A. R., Shen, Z., Ohayon, Y. P., Wang, T., Kizer, M. E., Sha, R., Mao, C., Yan, H., Zhang, X., Liao, S., Ding, B., Chakraborty, B., Jonoska, N., Niu, D., Gu, H., Chao, J., Gao, X., Li, Y., ... Seeman, N. C. (2019). Paranemic Crossover DNA: There and Back Again. Chemical reviews, 119(10), 6273-6289. https://doi.org/10.1021/acs.chemrev.8b00207
Anderson, N. T., Ren, S., Chao, J., Dinolfo, P. H., & Wang, X. (2019). Exploiting Plasmon-Mediated Energy Transfer To Enhance End-to-End Efficiency in a DNA Origami Energy Transfer Array. ACS Applied Nano Materials, 2(9), 5563-5572. https://doi.org/10.1021/acsanm.9b01137
He, Z., Han, Z., Kizer, M., Linhardt, R. J., Wang, X., Sinyukov, A. M., Wang, J., Deckert, V., Sokolov, A. V., Hu, J., & Scully, M. O. (2019). Tip-Enhanced Raman Imaging of Single-Stranded DNA with Single Base Resolution. Journal of the American Chemical Society, 141(2), 753-757. https://doi.org/10.1021/jacs.8b11506
Kizer, M. E., Deng, Y., Kang, G., Mikael, P. E., Wang, X., & Chung, A. J. (2019). Hydroporator: A hydrodynamic cell membrane perforator for high-throughput vector-free nanomaterial intracellular delivery and DNA origami biostability evaluation. Lab on a chip, 19(10), 1747-1754. https://doi.org/10.1039/c9lc00041k
Recent Publications
Deng, Y., Rada, M., Kizer, M., Wang, X., Cheon, D. J., & Chung, A. J. (2020). Inertial microfluidic cell hydroporator (IMCH) for high-throughput & single-step intracellular molecule delivery. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 169-170). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.
Duan, J., Wang, X., & Kizer, M. E. (2020). Biotechnological and Therapeutic Applications of Natural Nucleic Acid Structural Motifs. Topics in current chemistry, 378(2), [26]. https://doi.org/10.1007/s41061-020-0290-z
Kwon, P. S., Ren, S., Kwon, S. J., Kizer, M. E., Kuo, L., Xie, M., Zhu, D., Zhou, F., Zhang, F., Kim, D., Fraser, K., Kramer, L. D., Seeman, N. C., Dordick, J. S., Linhardt, R. J., Chao, J., & Wang, X. (2020). Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition. Nature Chemistry, 12(1), 26-35. https://doi.org/10.1038/s41557-019-0369-8
Anderson, N. T., Ren, S., Chao, J., Dinolfo, P. H., & Wang, X. (2019). Exploiting Plasmon-Mediated Energy Transfer To Enhance End-to-End Efficiency in a DNA Origami Energy Transfer Array. ACS Applied Nano Materials, 2(9), 5563-5572. https://doi.org/10.1021/acsanm.9b01137
Cheng, S., Wantuch, P. L., Kizer, M. E., Middleton, D. R., Wang, R., Dibello, M., Li, M., Wang, X., Li, X., Ramachandiran, V., Avci, F. Y., Zhang, F., Zhang, X., & Linhardt, R. J. (2019). Glycoconjugate synthesis using chemoselective ligation. Organic and Biomolecular Chemistry, 17(10), 2646-2650. https://doi.org/10.1039/c9ob00270g