Contact Information
1304 W Springfield Ave
Urbana, IL 61801
Research Areas
Additional Campus Affiliations
Senior Research Scientist, Micro and Nanotechnology Lab
Senior Research Scientist, Carl R. Woese Institute for Genomic Biology
Biography
Dr. Xing Wang is a nucleic acids biochemist and structural DNA nanotechnologist at UIUC. He received a Ph.D. in Chemistry from New York University. He did his postdoctoral training at Princeton University to explore novel functions of synthetic RNAs in genome editing. He is a recipient of the Mikashi Awards in 2021. Before joining UIUC, Dr. Wang was an Assistant Professor in the Department of Chemistry and Chemical Biology and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute.
Research Interests
Dr. Wang is the inventor of the DNA Star platform that utilizes designer DNA nanostructures (DDN) to create biosensors and biomedicines. His Nucleic Acids Programming Lab engineers DDNs that offer a plug-and-play platform to create functional nanomaterials with aptamers, peptides/nanobodies, or quantum dots for developing (1) ultrasensitive and inexpensive biosensors for rapid disease diagnostics in both point-of-care and high throughput settings, (2) effective therapeutic candidates for infectious disease treatment/prevention and cancer immunotherapy, (3) new strategies and reagents for high resolution imaging. His research group is supported by the NIBIB, NIAID, NIDCR, NIAAA, UIUC DREMES Center, NSF, and Mikashi Awards of IGB.
Education
Ph.D. in Chemistry, New York University
Academic Service
Dr. Wang directs the Nucleic Acids Programming Lab (NAPL) at UIUC. He is the co-director of the Center for Pathogen Diagnostics (CPD). He is affiliated with HMNTL and IGB.
Highlighted Publications
Ren, S., Fraser, K., Kuo, L., Chauhan, N., Adrian, A. T., Zhang, F., Linhardt, R. J., Kwon, P. S., & Wang, X. (2022). Designer DNA nanostructures for viral inhibition. Nature Protocols, 17(2), 282-326. https://doi.org/10.1038/s41596-021-00641-y
Chauhan, N., & Wang, X. (2021). Nanocages for virus inhibition. Nature Materials, 20(9), 1176-1177. https://doi.org/10.1038/s41563-021-01088-y
Li, N., Canady, T. D., Huang, Q., Wang, X., Fried, G. A., & Cunningham, B. T. (2021). Photonic resonator interferometric scattering microscopy. Nature communications, 12(1), [1744]. https://doi.org/10.1038/s41467-021-21999-3
Kwon, P. S., Ren, S., Kwon, S. J., Kizer, M. E., Kuo, L., Xie, M., Zhu, D., Zhou, F., Zhang, F., Kim, D., Fraser, K., Kramer, L. D., Seeman, N. C., Dordick, J. S., Linhardt, R. J., Chao, J., & Wang, X. (2020). Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition. Nature Chemistry, 12(1), 26-35. https://doi.org/10.1038/s41557-019-0369-8
He, Z., Han, Z., Kizer, M., Linhardt, R. J., Wang, X., Sinyukov, A. M., Wang, J., Deckert, V., Sokolov, A. V., Hu, J., & Scully, M. O. (2019). Tip-Enhanced Raman Imaging of Single-Stranded DNA with Single Base Resolution. Journal of the American Chemical Society, 141(2), 753-757. https://doi.org/10.1021/jacs.8b11506
Kizer, M. E., Linhardt, R. J., Chandrasekaran, A. R., & Wang, X. (2019). A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures. Small, 15(26), [1805386]. https://doi.org/10.1002/smll.201805386
Wang, X., Chandrasekaran, A. R., Shen, Z., Ohayon, Y. P., Wang, T., Kizer, M. E., Sha, R., Mao, C., Yan, H., Zhang, X., Liao, S., Ding, B., Chakraborty, B., Jonoska, N., Niu, D., Gu, H., Chao, J., Gao, X., Li, Y., ... Seeman, N. C. (2019). Paranemic Crossover DNA: There and Back Again. Chemical reviews, 119(10), 6273-6289. https://doi.org/10.1021/acs.chemrev.8b00207
Recent Publications
Chakraborty, B., Das, S., Gupta, A., Xiong, Y., T-V, V., Kizer, M. E., Duan, J., Chandrasekaran, A. R., & Wang, X. (2022). Aptamers for Viral Detection and Inhibition. ACS Infectious Diseases, 8(4), 667-692. https://doi.org/10.1021/acsinfecdis.1c00546
Chauhan, N., Xiong, Y., Ren, S., Dwivedy, A., Magazine, N., Zhou, L., Jin, X., Zhang, T., Cunningham, B. T., Yao, S., Huang, W., & Wang, X. (2022). Net-Shaped DNA Nanostructures Designed for Rapid/Sensitive Detection and Potential Inhibition of the SARS-CoV-2 Virus. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.2c04835
Li, N., Wang, X., Tibbs, J., Che, C., Peinetti, A. S., Zhao, B., Liu, L., Barya, P., Cooper, L., Rong, L., Wang, X., Lu, Y., & Cunningham, B. T. (2022). Label-Free Digital Detection of Intact Virions by Enhanced Scattering Microscopy. Journal of the American Chemical Society, 144(4), 1498-1502. https://doi.org/10.1021/jacs.1c09579
Li, N., Zhao, B., Stavins, R., Peinetti, A. S., Chauhan, N., Bashir, R., Cunningham, B. T., King, W. P., Lu, Y., Wang, X., & Valera, E. (2022). Overcoming the limitations of COVID-19 diagnostics with nanostructures, nucleic acid engineering, and additive manufacturing. Current Opinion in Solid State and Materials Science, 26(1), [100966]. https://doi.org/10.1016/j.cossms.2021.100966
Ren, S., Fraser, K., Kuo, L., Chauhan, N., Adrian, A. T., Zhang, F., Linhardt, R. J., Kwon, P. S., & Wang, X. (2022). Designer DNA nanostructures for viral inhibition. Nature Protocols, 17(2), 282-326. https://doi.org/10.1038/s41596-021-00641-y