Douglas Mitchell's research group has created a new bioinformatics tool, RODEO, that promises to capture the breadth of microbial biosynthetic potential.
Douglas A. Mitchell
Professor Mitchell received his undergraduate degree in chemistry from Carnegie Mellon University in 2002. After a short internship in medicinal chemistry at Merck Research Laboratories, he obtained his Ph.D. from the University of California, Berkeley in 2006. For postdoctoral studies, he worked with Jack Dixon at the University of California, San Diego. Professor Mitchell joined the University of Illinois faculty in 2009 and has research interests that span the interface of chemistry and biology.
To view the Mitchell Lab twitter page, see:https://twitter.com/theDAMlab
- reactivity-based natural product discovery; complex molecule structural elucidation and derivatization; structure-activity relationships and mode of action determination of biomedically important compounds; natural product chemical biology: mechanistic enzymology of key biosynthetic enzymes; structure-function studies of complex small molecules; and development of bioinformatic and bioorganic methodology to accelerate the discovery of biomedically important compounds
Our primary objective is to use a blend of chemical and biological approaches to address the alarming rise in antibiotic resistance. In this endeavour, we seek to identify and characterize novel antibiotic compounds. Our research involves the characterization of novel natural products and employs synthetic methods to reveal both biological mode of action and structure-activity relationships. Further, we evaluate the mechanistic details of key biosynthetic enzymes for the purposes of analog generation. Taken together, our work aims to expedite the discovery of future medicines from biological sources. Of special interest are compounds that only kill pathogenic bacteria or directly target mechanisms of virulence. Unlike currently deployed antibiotics, which exclusively target essential life processes, our strategy holds great potential in delaying resistance. The Mitchell laboratory is a multidisciplinary team that draws methodology from the fields of chemical biology, organic chemistry, microbiology, pharmacology, structural biology, and bioinformatics.
For a more detailed research description see: http://www.scs.illinois.edu/mitchell/research.html
Distinctions / Awards
- 2015 National Fresenius Award, Phi Lambda Upsilon (National Chemistry Honor Society)
- 2015 Camille Dreyfus Teacher-Scholar Award
- 2015-2016 Helen Corley Petit Scholar (UIUC College of Liberal Arts and Sciences)
- 2015 Pfizer Award in Enzyme Chemistry (ACS Division of Biological Chemistry)
- Tomorrow's PI: Genome Technology magazine
- Packard Fellowship in Science and Engineering
- NIH Director's New Innovator Award
In The News
Douglas Mitchell is the recipient of the 2016 National Fresenius Award.
Douglas_Mitchell has been named as a recipient of one of this year's Dreyfus Teacher-Scholar Awards.
Douglas Mitchell is the recipient of the 2015 Pfizer Award in Enzyme Chemistry. He is cited for his outstanding work in enzyme chemistry where the presence of enzyme action is unequivocally demonstrated.
Antibiotic resistance is depleting our arsenal against deadly diseases and infections, such as tuberculosis and Staph infections, but recent research shows promise to speed up the drug discovery process.