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Samy Meroueh

Professor of Biochemistry

Additional Campus Affiliations

Chemical Biology and Cancer Drug Discovery Laboratory
Phil and Ann Sharp Scholar in Cancer Drug Discovery

Recent Publications

Brenner, R. J., Landgraf, A. D., Bum-Erdene, K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62(22), 3206-3213. https://doi.org/10.1021/acs.biochem.3c00378

Bum-Erdene, K., Ghozayel, M. K., Zhang, M. J., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction. RSC Medicinal Chemistry, 14(9), 1803-1816. https://doi.org/10.1039/d3md00264k

Bum-Erdene, K., Yeh, I. J., Gonzalez-Gutierrez, G., Ghozayel, M. K., Pollok, K., & Meroueh, S. O. (2023). Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists. Journal of Medicinal Chemistry, 66(1), 266-284. https://doi.org/10.1021/acs.jmedchem.2c01189

Hussain, M. S., Liu, D., Alilain, W. J., & Meroueh, S. O. (2023). Covalent Fragment Inhibits RhoA Activation by Guanine Exchange Factors. ACS Chemical Neuroscience, 14(14), 2509-2516. https://doi.org/10.1021/acschemneuro.3c00154

Landgraf, A. D., Yeh, I. J., Ghozayel, M. K., Bum-Erdene, K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation. ChemMedChem, 18(16), Article e202300272. https://doi.org/10.1002/cmdc.202300272

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