| Martin D. Burke |
Synthesis and study of small molecules with protein-like functions; molecular prosthetics; synthesis of complex natural products; iterative cross-coupling; MIDA boronates |
| Jefferson Chan |
Advanced imaging agents for neurological disorders and cancer; synthesis of activity-based sensing probes to discover new mechanisms of premature aging; chemically responsive platforms for on-demand and site-selective drug delivery
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| Martin Gruebele |
In vitro, in cell, and in vivo protein folding; protein-RNA interactions; protein-protein interaction dynamics |
| Hee-Sun Han |
Dissecting complex molecular networks in healthy/diseased tissues; single virus genomics; single cell transcriptomics; in vitro/in vivo imaging; quantum dots; microfluidics; high-throughput technologies |
| Paul J. Hergenrother |
Use of small molecules to identify and define novel targets for the treatment of cancer, neurodegeneration, and drug-resistant bacteria |
| Zaida (Zan) Luthey-Schulten |
Simulations of in vivo stochastic processes in single cells and colonies using GPUs; physics of metabolic networks; evolution of translation; dynamical networks of protein-RNA interactions; statistical mechanics of the genome and DNA replication |
| Anastasia C. Manesis |
Bioinorganic chemistry of metalloproteins; structural and mechanistic studies of diheme and multiheme enzymes as it relates to O2 activation chemistry; bioinformatics-guided approaches to the identification of novel metallocofactors within unexplored protein superfamilies; metalloenzyme catalysis; microbial oxidative stress response; protein engineering. |
| Angad P. Mehta |
Synthetic and molecular engineering platforms to: (i) recapitulate eukaryotic cell evolution, particularly, organelle evolution, (ii) develop synthetic tools for genome editing and (iii) develop vaccine candidates by constructing synthetic biochemical pathways |
| Liviu M. Mirica |
Development of bifunctional therapeutic and diagnostic agents for amyloid peptide disorders such as Alzheimer’s disease; study of the role of transition metal ions in neurodegenerative diseases |
| Douglas A. Mitchell |
Natural product chemical biology; mechanistic enzymology; structure-function studies of complex small molecules; bioinformatic and bioorganic methodology to accelerate biomedical discovery |
| Eric Oldfield |
Drug discovery and NMR/X-ray |
| Lisa Olshansky |
Switchable artificial metalloproteins for the investigation of enzyme mechanism; application to renewable energy conversion and in the development of targeted therapeutics |
| Scott K. Silverman |
DNA as an enzyme |
| Jonathan V. Sweedler |
Neurochemistry: the characterization of unusual neurotransmitters and neuromodulators and the determination of their function |
| Wilfred A. van der Donk |
Antibiotic biosynthesis; combinatorial chemistry of phosphonates; enzymology |